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Oxygen is a strong trigger for cellular reactions, however there are few comparative investigations assessing the effects over a large vary of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight wholesome subjects (32 males/16 females; age: 43.7 ± 13.Four years, peak: 172.7 ± 10.07 cm; weight 68.4 ± 15.7 kg) were randomly assigned, and blood samples have been taken earlier than and a couple of h after each publicity. Microparticles (MPs) expressing proteins particular to different cells were analyzed, together with platelets (CD41), neutrophils (CD66b), endothelial cells (CD146), and microglia (TMEM). Phalloidin binding and thrombospondin-1 (TSP), which are associated to neutrophil and platelet activation, respectively, were also analyzed. The responses were discovered to be totally different and generally opposite. Significant elevations have been recognized for MPs expressing CD41, CD66b, TMEM, and phalloidin binding in all situations but for 1.Four ATA, which elicited important decreases. Few adjustments were found for CD146 and TSP. Regarding OPB, additional investigation is required to totally understand the future purposes of such findings.
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發表於 2025-9-5 21:22:07