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Blood oxygen stage dependent (Bold) fMRI is a common technique for measuring mind activation that might be affected by low-stage carbon monoxide (CO) publicity from, e.g. smoking. This study aimed to probe the vulnerability of Bold fMRI to CO and determine whether or not it might represent a big neuroimaging confound. Low-level (6 ppm exhaled) CO results on Bold response were assessed in 12 healthy never-smokers on two separate experimental days (CO and air control). MRI duties have been breath-holds (hypercapnia), visible stimulation and fingertapping. Bold fMRI response was lower throughout breath holds, visual stimulation and fingertapping within the CO protocol compared to the air management protocol. Behavioural and physiological measures remained unchanged. We conclude that Bold fMRI could be susceptible to adjustments in baseline CO, and counsel exercising warning when imaging populations exposed to elevated CO ranges. Further work is required to fully elucidate the impact on CO on fMRI and its underlying mechanisms.
Here is my blog post; BloodVitals SPO2 device |
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